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氨酸增强了上皮的身份,并降低了肺癌的攻击性

Vignesh Ramesh^1,2, Paradesi Naidu Gollavilli^1,2, Luisa Pinna¹

¹Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.

EMBO molecular medicine

|September 28, 2023

概括

像 propionate 这样的短链脂肪酸可以逆转癌症.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

皮质转介质过渡 (EMT) 对癌症转移和化疗耐药性至关重要.
从药理上定位EMT在癌症治疗中提出了重大挑战.

研究的目的:

研究短链脂肪酸 (SCFA) 在非小细胞肺癌 (NSCLC) 和EMT中的作用.
探索酸作为一种潜在的治疗药物来对抗NSCLC的进展和抗化学性.

主要方法:

使用了以EMT为重点的整合功能基因组方法.
使用肺癌细胞系进行了体外实验,并使用小鼠模型进行了体内研究.
通过p300.00介导的H3K27乙化进行分析的染色质重塑.

主要成果:

在NSCLC患者中发现了 propionate/butanoate 和 EMT 之间的反向关联.
酸治疗逆转了EMT,增强了表皮特征,并在体外减少了侵略性表型.
在小鼠模型中,propionate降低了转移潜力和淋巴结传播.
证明酸通过通过p300通过H3K27乙化诱导上皮细胞状态.

结论:

氨酸的使用显示了治疗潜力,可以降低NSCLC的攻击性.
这些发现表明,酸可能是对抗NSCLC转移和化疗抵抗的可行策略.
对于NSCLC治疗酸的进一步临床研究是有必要的.

关键词:

乙化 H3K27 乙化表皮细胞-介质细胞过渡.代谢抑制剂的代谢抑制剂转移转移转移转移酸 propionate 的使用方法

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