在患有性亚血症的猫身上,血清粉样蛋白A
Laura Degenhardt1, Roswitha Dorsch1, Katrin Hartmann1
1LMU Small Animal Clinic, Center for Clinical Veterinary Medicine, LMU München, Veterinärstraße 13, 80539, Munich, Germany.
Veterinary world
|September 28, 2023
概括
患有病的猫的血清粉样蛋白A (SAA) 水平并没有有效地区分急性损伤与慢性病,也没有预测结果. SAA度与中性粒细胞计数,白蛋白和尿蛋白/肌素比率相关.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 生物化学 生物化学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 血清粉样蛋白A (SAA) 是一种急性阶段蛋白质,在猫的炎症期间升高.
- 它在猫性病中的作用,包括区分急性损伤 (AKI) 与慢性病 (CKD),以及其预后价值仍然不清楚.
研究的目的:
- 为了评估SAA度在亚体的猫.
- 确定SAA是否可以区分AKI,CKD和急性CKD (AoC).
- 评估SAA作为预后标志物及其与临床参数的相关性.
主要方法:
- 对48只亚体性猫 (肌素>250μmol/L) 的前性研究,不包括前和后病因.
- 通过度检测免疫试验测量SAA度.
- 统计分析包括曼-惠特尼U,克鲁斯卡尔-瓦利斯,奇方,费舍尔的精确和斯皮尔曼相关性测试.
主要成果:
- 在44%的亚组猫中,SAA增加,但在AKI,CKD和AOC组之间的SAA度中没有发现显著差异.
- 在幸存者和非幸存者之间,SAA水平的中位数没有显著差异.
- SAA度与中性粒细胞计数,白蛋白度和尿蛋白/肌素 (UP/C) 相对相关.
结论:
- SAA的升高发生在猫类性病中,但不区分AKI和CKD.
- 在这些情况下,SAA不是可靠的预后标志物.
- 并发症可能会影响SAA度,这与炎症和脏标志物相关.
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