用于痴呆症治疗的PDE5抑制剂药物
Atticus H Hainsworth1,2, Ottavio Arancio3, Fanny M Elahi4
1Molecular & Clinical Sciences Research Institute St George's University of London London UK.
Alzheimer's & dementia (New York, N. Y.)
|September 28, 2023
概括
基化酶-5 (PDE5) 抑制剂已经用于其他疾病,在降低痴呆风险方面显示出希望. 需要进一步的临床试验来探索它们对阿尔茨海默病和相关痴呆症的潜力.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 老年学是一门学科.
背景情况:
- 阿尔茨海默病和相关痴呆症 (ADRD) 带来了严重的医疗保健挑战,治疗选择有限.
- 重用现有的药物是ADRD预防和治疗的可行策略.
- 二酶-5 (PDE5) 存在于脑细胞和血管中,这表明它在认知功能中起作用.
研究的目的:
- 评估固酶-5 (PDE5) 抑制剂在预防和治疗ADRD方面的潜力.
- 审查PDE5抑制剂对认知功能和痴呆风险的影响现有数据.
- 确定选择适当的PDE5抑制剂的关键因素,用于ADRD的未来临床试验.
主要方法:
- 对动物研究的审查,证明PDE5抑制剂的认知益处.
- 对现实世界的人类数据的分析,将西尔代纳菲尔和瓦尔代纳菲尔使用与降低痴呆风险联系起来.
- 考虑药理性质,如大脑透,耐受性和半衰期.
主要成果:
- 动物研究表明,PDE5抑制剂可以增强突触功能和认知能力.
- 人类数据表明,西尔德纳菲尔和瓦尔德纳菲尔使用与痴呆症风险降低之间存在关联.
- 虽然对塔达拉菲尔的一项试验对急性作用中立,但对脑血管或突触功能的慢性作用需要进一步调查.
结论:
- 经批准的PDE5抑制剂,在临床上用作血管扩张剂,有可能在痴呆症治疗中重新利用.
- 进一步的前性临床试验至关重要,以确认PDE5抑制剂对ADRD的疗效和安全性.
- 对于试验的药物选择,应考虑大脑透率,老年人群的耐受性,半衰期和非目标效应.
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