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通过结合Tc-PSMA SPECT/CT和多参数MRI和定量参数来提高原发性前列腺癌的诊断效果

Yu Zhang^1,2,3, Yuanying Shi¹, Liefu Ye^4,5

¹Department of Nuclear Medicine, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.

Frontiers in oncology

|September 28, 2023

概括

这项研究发现,将99mTc-PSMA SPECT/CT和多参数MRI (mpMRI) 结合起来,可以改善前列腺癌 (PCa) 检测. 最大标准化吸收值与最小明显扩散系数 (SUVmax/ADCmin) 的比率是诊断PCa的关键成像参数.

科学领域:

放射学放射学是一门学科.
在瘤学瘤学.
医疗成像医学成像

背景情况:

前列腺癌 (PCa) 诊断依赖于准确的成像,以区分恶性和良性病变.
多参数磁共振成像 (mpMRI) 和99mTc-PSMA SPECT/CT是PCa评估的先进成像方式.
对比这些技术的诊断效果对于优化患者管理至关重要.

研究的目的:

为了前性地评估和比较99mTc-PSMA SPECT/CT和mpMRI在检测原发性前列腺癌中的诊断性能.
评估像SUVmax,ADCmin这样的成像参数的实用性,以及它们的比率,以区分良性和恶性前列腺病变.

主要方法:

56名疑似PCa的男性接受了99mTc-PSMA SPECT/CT和mpMRI.
图像参数包括最大标准化吸收值 (SUVmax) 和最小明显扩散系数 (ADCmin).
计算SUVmax/ADCmin的比率并对其诊断值进行分析.

主要成果:

99mTc-PSMA SPECT/CT和mpMRI都显示出PCa检测的高灵敏度和特异性,它们之间没有显著差异 (97.7%与90.9%的灵敏度,75.0%与75.0%的特异性).
与SUVmax或ADCmin单独相比,SUVmax和ADCmin的联合比率显示出更高的诊断准确性 (AUC).
SUVmax/ADCmin与格里森得分正相关,表明其在预测癌症攻击性和风险分层方面的价值.

结论:

结合99mTc-PSMA SPECT/CT和mpMRI,可以提高前列腺癌检测的诊断效率.
SUVmax/ADCmin比率是前列腺病变差异诊断和预测高风险疾病的有价值的成像参数.

关键词:

磁共振成像技术的使用前列腺癌是前列腺癌.前列腺特异性膜抗原前列腺特异性膜抗原单光子发射计算机断层扫描.技术的放射性同位素.

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