塞福拉/苏尔巴克坦诱导的凝血障碍的危险因素
Wan Miao1, Jinlin Guo1, Huifang Cheng1
1Department of Pharmacy, Shanxi Provincial People's Hospital, Taiyuan, Shanxi Province, People's Republic of China.
Infection and drug resistance
|September 28, 2023
概括
晚年和长时间的治疗增加了塞福拉/苏尔巴克坦诱导的凝血病 (CIC) 的风险. 补充维生素K可能会防止CIC. 提格环素和烯酸并没有增加出血风险.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
- 血液学 血液学 血液学
背景情况:
- 塞福拉/苏尔巴克坦是一种用于各种感染的抗生素组合.
- 凝血障碍已经被事地与塞福拉/苏尔巴克坦相关联.
- 同时服用tigecycline或valproic acid对赛福拉/苏尔巴克坦诱导的凝血病 (CIC) 的影响尚不清楚.
研究的目的:
- 调查与塞福拉/苏尔巴克坦诱导的凝血病 (CIC) 相关的风险因素.
- 为了确定tigecycline或valproic酸是否会加剧CIC的风险.
- 识别潜在的防护因素对CIC.
主要方法:
- 一个回顾性,单中心,嵌套的病例控制研究.
- 使用倾向分数匹配 (PSM) 来平衡人口特征.
- 使用条件后勤回归和ROC曲线分析来确定风险因素和最佳切断值.
主要成果:
- 晚年,延长治疗时间和较高的塞福拉/苏尔巴克坦总剂量是CIC的独立风险因素.
- 同时服用维生素K是对CIC的独立保护因素.
- 没有发现tigecycline和valproic acid与CIC风险增加有关.
结论:
- 先进的年龄和长时间的治疗时间是赛福拉/苏尔巴克坦诱导的凝血病的重要危险因素.
- 补充维生素K可以减轻CIC的风险.
- 同时使用tigecycline或valproic acid似乎不会增加CIC的风险.
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