当实践不能形成完美的学习曲线时 - - 精神分裂症和双相情感障碍的矛盾学习曲线是由不同的串行反应时间任务变体揭示的
Adrian Andrzej Chrobak1, Katarzyna Siuda-Krzywicka2, Zbigniew Soltys3
1Department of Adult Psychiatry, Jagiellonian University Medical College, Kraków, Poland.
Frontiers in psychiatry
|September 28, 2023
概括
精神分裂症 (SZ) 和双相情感障碍 (BD) 患者表现出受损的隐性运动学习. 一个新的串行反应时间任务 (SRTT) 证实了这些缺陷,为神经成像研究认知功能障碍铺平了道路.
科学领域:
- 认知神经科学 认知神经科学
- 神经心理学 神经心理学
- 精神病学是一个精神病学.
背景情况:
- 以前的研究表明,在精神分裂症 (SZ) 和双相情感障碍 (BD) 中,非典型的隐性运动学习.
- 隐性运动学习缺陷可能是这些患者群体认知功能障碍的基础.
研究的目的:
- 为了验证一个新的,MRI兼容的串行反应时间任务 (SRTT),用于评估隐式运动学习.
- 为了证实以前在SZ和BD患者中观察到的隐性运动学习缺陷,使用精细的SRTT.
主要方法:
- 186名参与者 (SZ,BD和健康对照 - HCs) 完成了双手SRTT的有限或无限响应时间版本.
- 隐式运动学习通过比较两个SRTT变体之间的性能指数来评估.
主要成果:
- 在有限响应时间和无限制响应时间SRTT版本之间,在隐性运动学习指数中没有发现显著差异.
- 与HC相比,SZ和BD患者的隐性运动学习显著减少.
- 两组患者都表现出与HC不同的矛盾学习模式;在SZ中,这种模式依赖于手.
结论:
- 有限的响应时间SRTT有效地复制了SZ和BD中中断隐性运动学习的发现.
- 这种经过验证的SRTT范式适用于未来的神经成像研究,以调查SZ和BD认知缺陷的神经基础.
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