外体非编码RNAs:结直肠癌转移的蓝图和治疗点
Bashdar Mahmud Hussen1,2, Sara Tharwat Abdullah3, Snur Rasool Abdullah4
1Department of Biomedical Sciences, College of Science, Cihan University-Erbil, Erbil, Kurdistan Region, 44001, Iraq.
Non-coding RNA research
|September 28, 2023
概括
外基因组携带非编码RNA (ncRNA),驱动结直肠癌 (CRC) 转移. 了解这些外体ncRNA为转移性CRC患者提供了潜在的新治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因,转移是死亡的主要驱动因素.
- 在CRC中转移涉及瘤微环境 (TME) 内的复杂分子机制.
- 外体,小的细胞外囊泡,作为TME内的细胞间通信的关键媒介.
研究的目的:
- 审查外体非编码RNAs (ncRNAs) 在结直肠癌 (CRC) 转移中的关键作用.
- 探索目前和潜在的治疗策略,针对转移性CRC的外体ncRNA.
- 强调需要进一步研究CRC转移中的外体ncRNAs的分子机制和临床应用.
主要方法:
- 文献综述侧重于外体非编码RNAs (ncRNAs) 和它们在结直肠癌 (CRC) 转移中的参与.
- 对外体miRNAs,circRNAs和lncRNAs在癌症进展中的调节功能进行当前研究的分析.
- 检查新兴的治疗途径和挑战,以向外体ncRNA用于CRC治疗.
主要成果:
- 外体ncRNAs,包括miRNAs,circRNAs和lncRNAs,显著影响细胞过程驱动CRC转移.
- 这些ncRNAs促进TME内部的通信,促进癌细胞迁移,入侵和耐药性.
- 外体ncRNA与CRC转移之间的精确分子联系尚未完全阐明.
结论:
- 外基因的ncRNA是转移性结直肠癌进展的关键参与者.
- 向外体ncRNAs是一个有希望的,但仍处于早期阶段的治疗策略,用于转移性CRC.
- 进一步的研究至关重要,以完善输送方法,确定新的点,并验证基于外体ncRNA的疗法的安全性和有效性.
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