一次性扩散性大B细胞直肠淋巴瘤在一个非免疫抑制的病人与性结肠炎
Sofia Saraiva1, Sónia Bernardo2, Samuel Fernandes2
1Gastroenterology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal.
GE Portuguese journal of gastroenterology
|September 28, 2023
概括
初级结肠直肠淋巴瘤很少见,特别是在没有免疫抑制的性结肠炎 (UC) 患者中. 这一案例凸显了模仿UC爆发的直肠淋巴瘤的诊断挑战,表明了其他发展途径.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 初级结肠直肠淋巴瘤是罕见的,直肠参与是不常见的.
- 炎症性肠病 (IBD) 患者的发展通常与免疫抑制疗法有关.
- 从性结肠炎 (UC) 爆发区分结肠直肠淋巴瘤可能是临床上具有挑战性的.
研究的目的:
- 在UC患者中报告直肠非霍奇金淋巴瘤病例.
- 探索UC中淋巴瘤发展的替代机制.
- 突出UC患者管理的诊断挑战.
主要方法:
- 一个42岁的男性的病例报告,有7年的UC病史.
- 患者呈现了难治症状,包括粘液性腹,紧张肌肉,直肠痛和体重减轻.
- 诊断程序包括下胃肠道内镜和组织病理学分析.
主要成果:
- 组织病理学证实了直肠的非霍奇金扩散性大B细胞淋巴瘤 (DLBCL).
- 该患者之前没有接触过免疫调节剂.
- 症状对优化治疗是不耐药的.
结论:
- 建议在UC患者中发展DLBCL的替代机制.
- 这一案例强调了区分淋巴瘤与UC爆发的诊断复杂性.
- 强调在UC患者中保持警监测的重要性.
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