在使用氧化治疗COVID-19和诱导性关节炎时需要考虑的眼科影响
1Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy. markzeppieri@hotmail.com.
World journal of experimental medicine
|September 28, 2023
概括
抗疟疾药Hydroxychloroquine (HCQ) 可能会在接受COVID-19治疗的患者中引起视网膜毒性. 监测至关重要,以尽量减少视力受损的风险,特别是长期使用或先前存在的条件.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 药理学 药理学 是一个学科.
背景情况:
- 抗疟疾药物氧化 (HCQ) 已被研究用于治疗COVID-19和相关关节炎.
- 已知HCQ会引起视网膜毒性,可能导致视力受损或丧失.
- HCQ视网膜毒性的确切机制涉及药物在视网膜色素表皮中的积累.
研究的目的:
- 讨论COVID-19患者中氧化 (HCQ) 诱导的视网膜毒性的风险.
- 要突出增加HCQ眼部不良事件风险的因素.
- 概述监测和最小化与COVID-19的HCQ治疗相关的眼科风险的策略.
主要方法:
- 关于氧化 (HCQ) 在COVID-19中使用的文献综述.
- 对HCQ视网膜毒性的已知机制和风险因素的分析.
- 讨论眼部不良事件的监测和管理策略.
主要成果:
- 在COVID-19中使用氧化 (HCQ) 存在视网膜毒性的风险.
- 风险因素包括长期使用,高剂量和先前存在的视网膜疾病.
- 视网膜色素上皮质中的积累是毒性的疑似原因.
结论:
- 眼科监测对于接受氧化 (HCQ) 治疗COVID-19的患者至关重要.
- 尽量减少HCQ的剂量和持续时间,并查视网膜疾病可以减轻风险.
- 需要进一步的研究,以充分理解和管理HCQ诱导的视网膜毒性.
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