在CAR-T细胞治疗后的长期生存护理
Robert Puckrin1, Kareem Jamani1, Victor H Jimenez-Zepeda1,2
1Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta, Canada.
European journal of haematology
|September 28, 2023
概括
化学抗原受体 (CAR) T细胞治疗幸存者面临长期的毒性. 本综述详细介绍了管理神经毒性,细胞衰竭,感染和生育问题等晚期影响,以改善CAR T细胞存活护理.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 细胞疗法细胞疗法
背景情况:
- 化学抗原受体 (CAR) T细胞疗法是一种革命性的癌症治疗方法.
- 虽然细胞因子释放综合征和神经毒性等急性毒性是可以控制的,但长期影响需要注意.
- 越来越多的CAR T细胞疗法使用和长期幸存者需要关注晚期并发症.
研究的目的:
- 审查并提供一种实际的方法来管理CAR T细胞治疗幸存者的晚期影响.
- 要突出常见和具有挑战性的晚期并发症,需要具体的管理策略.
- 为了指导使用CAR T细胞治疗的患者的长期生存护理.
主要方法:
- 文献综述侧重于CAR T细胞治疗的晚期毒性.
- 综合当前关于管理持久性或晚发性并发症的知识.
- 为幸存者护理制定一个实际框架.
主要成果:
- 幸存者可能会经历晚期发作的神经毒性,延长的细胞衰竭和延迟的免疫复原.
- 感染的风险增加,随后的恶性瘤,器官功能障碍和心理困扰都被注意到.
- 对于长期幸存者来说,生育方面的影响是重要的考虑因素.
结论:
- 对急性毒性的有效管理允许专注于长期的CAR T细胞治疗后果.
- 积极的评估和管理策略对于CAR T细胞生存至关重要.
- 解决晚期影响对于优化CAR T细胞接受者的生活质量至关重要.
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