[激素性鼻炎症状的控制在患有低甲状腺症的患者中:病原遗传和临床方面]
A I Kryukov1,2, N M Chernykh3, E V Nosulya1
1L.A. Sverzhevsky Scientific Research Clinical Institute of Otorhinolaryngology, Moscow, Russia.
Vestnik otorinolaringologii
|September 28, 2023
概括
在甲状腺功能低下症患者中,莫马塔鼻喷剂有效降低了慢性鼻炎症状. 这种治疗改善了鼻腔呼吸,并降低了TGF-β1和NOx等炎症标志物.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺功能低下症的慢性鼻炎是不太了解,呈现诊断挑战和缺乏治疗指南.
- 在这些患者中,Levothyroxine替代疗法往往无法解决持久性鼻炎症状.
研究的目的:
- 评估内葡萄糖皮质类固醇在患有甲状腺功能低下症的患者慢性鼻炎的治疗效果.
主要方法:
- 60名患有慢性鼻炎和甲状腺功能低下症的患者接受了mometasone鼻喷雾剂 (100微克每天一次,持续2个月).
- 症状评估包括视觉模拟尺度和前部活性鼻腔测量.
- 测量了鼻腔粘膜运输,鼻分泌中的转化生长因子β1 (TGF-β1),以及酸盐/酸盐 (NOx) 含量.
主要成果:
- 莫梅塔松鼻雾剂显著减少了鼻炎症状,包括鼻腔阻塞和鼻,并改善了鼻腔呼吸.
- 治疗后的分析显示,鼻分泌物中TGF-β1和NOx度下降.
- 治疗前TGF-β1和NOx水平的升高表明它们在甲状腺功能低下患者观察到的 edematous 过敏变化中的作用.
结论:
- 鼻内用莫梅松是治疗低甲状腺症患者慢性鼻炎的有效治疗方法.
- 降低TGF-β1和NOx的含量表明,mometasone在这种患者群体中具有治疗效果的潜在机制.
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