孕期母亲高血压疾病与婴儿神经发育的关联
Bo Huang1,2, Yifan Wang1,3, Yangqian Jiang3
1State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Journal of biomedical research
|September 28, 2023
概括
怀孕期高血压障碍 (HDP) 与婴儿神经发育不佳有关,特别是在双胞胎的总体运动技能和认知方面. 这项研究澄清了母亲患有HDP的1岁婴儿的风险.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 发育神经科学的发展神经科学.
背景情况:
- 妊娠高血压障碍 (HDP) 包括诸如子宫前和慢性高血压等疾病,对婴儿神经发育有着争论的影响.
- 之前的研究对母亲的HDP与婴儿神经发育结果之间的关系提出了不一致的发现.
- 了解这些关联对于早期干预和改善婴儿健康结果至关重要.
研究的目的:
- 调查妊娠高血压疾病 (HDP) 与1岁婴儿神经发育结果之间的关联.
- 为了区分单胎与双胎怀孕的效果.
- 提供有关母亲HDP对婴儿神经发育影响的最新证据.
主要方法:
- 利用了江苏出生队列的数据,包括2576个单胎和261个双胎怀孕.
- 使用贝利婴儿和幼儿发展查测试尺度 (第三版) 评估婴儿神经发育.
- 采用一般线性回归和波松回归模型来分析母亲HDP与婴儿神经发育分数和风险之间的关联.
主要成果:
- 在单子怀孕中,母亲慢性高血压与较低的总运动分数和非最佳总运动发育风险增加有关.
- 在双胞胎怀孕中,母亲的HDP与认知,感受性沟通和总体运动发育的较低得分有关.
- 在双胞胎怀孕中,患有HDP的母亲所生婴儿,患有非最佳总运动发育的风险更高.
结论:
- 在怀孕期间患有高血压疾病的母亲生下的婴儿可能在1岁时表现出神经发育受损的结果.
- 该研究强调了认知,沟通和运动技能的特定脆弱性,特别是在双胞胎怀孕中.
- 这些发现强调了监测婴儿在子宫内暴露于HDP的神经发育的重要性.
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