对于结石的重复冲击波和石灰疗程之间的理想间隔:一个随机对照试验
Mohamed Fadallah1, Ahmed Abdelhalim1,2, Abdelwahab Hashem1
1Urology Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
Journal of endourology
|September 28, 2023
概括
在体外冲击波石治疗 (SWL) 疗程之间隔7天的时间,可以使功能完全恢复. 较短的间隔可能会损害功能,并降低治疗结石的成功率.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物医学工程 生物医学工程
背景情况:
- 身体外冲击波石 (SWL) 是对结石的常见治疗方法.
- 为了确保功能恢复,重复的SWL会话之间的最佳间隔尚未得到确定的.
研究的目的:
- 为了确定结石连续SWL会话之间的理想时间间隔.
- 评估不同SWL间隔对管和球功能的影响.
主要方法:
- 166名结石≤20毫米的患者被随机分为三组,在3,7或14天后接受第二次SWL治疗.
- 通过尿路生物标志物 (KIM-1,NGAL,IL-18),蛋白质/肌素比率和同位素扫描来评估功能.
- 在3个月后,通过非对比CTCT评估治疗的成功.
主要成果:
- 所有患者在SWL后都显示出 tubular生物标志物和蛋白质/肌素比率升高,水平在7天和14天恢复到基线,但在3天仍然升高.
- SWL的成功率为73.6% (3天间隔),83.7% (7天间隔) 和81% (14天间隔).
- 在3天间隔组中,发现侧功能显著下降.
结论:
- 建议在SWL疗程之间隔7天,以获得最佳的结石治疗.
- 这段时间允许功能完全恢复,改善治疗结果,防止损伤.
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