瘤坏死因子-α (-308G>A) 基因多态化及其与喘和亚托皮状态的关联
Anahita Razaghian1, Nima Parvaneh2, Ali Akbar Amirzargar3
1Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran. anahita.razaghian@gmail.com.
Iranian journal of allergy, asthma, and immunology
|September 28, 2023
概括
瘤坏死因子-α (TNF-α) 基因的遗传变异与喘有关. 特定的TNF基因多态,特别是位于-308位的AA基因型,与伊朗儿童喘易感性增加有关.
科学领域:
- 遗传学 是一个遗传学.
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
背景情况:
- 喘是一种广泛的慢性呼吸道疾病,受遗传因素的影响.
- 细胞因子多态,包括瘤坏死因子-α (TNF-α),与喘的发展有关.
- TNF-α是一种关键的炎症性细胞因子,影响非特异性气道炎症.
研究的目的:
- 为了研究TNF基因多态性在位置-308 (rs1800629) 和喘易感性之间的关联.
- 为了检查这种多态性和亚托匹克与非亚托匹克喘表型之间的关系.
主要方法:
- 对TNF (-308 A>G) 多态的基因定型使用聚合酶连锁反应与序列特定的原始体进行.
- 该研究包括86名儿科喘患者和470名来自同一种族背景的健康对照.
- 在74名喘患者身上进行了皮肤刺痛测试,以评估阿托皮.
主要成果:
- 与对照组相比,TNF (-308) 的同卵性AA基因型在喘患者中 (63.3%) 显著更常见.
- 在患者组中,GG基因型的流行率较低.
- 在喘患者 (85.5%) 中,TNF A (-308) 等位基因的频率明显高于对照组 (16.6%).
结论:
- TNF (-308) AA和AG基因型与伊朗儿童喘易感性增加有关.
- 在阿托皮性和非阿托皮性喘亚型之间或在喘严重程度组之间没有发现TNF (-308) 多态性的显著差异.
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