细胞原发性免疫缺陷在儿童中的放射性表现
Mitra Khalili1, Zahra Chavoshzadeh2, Sepideh Darougar3
1Department of Radiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. m.khalili76@yahoo.com.
Iranian journal of allergy, asthma, and immunology
|September 28, 2023
概括
在患有原发性免疫缺陷的儿童中,特别是慢性颗粒状细胞疾病 (CGD) 的成像检测结果显示,常见的表现如中枢淋巴腺病变和巩固. 早期识别有助于及时治疗和改善这些罕见遗传疾病的结果.
科学领域:
- 儿科放射学 儿科放射学
- 免疫学 免疫学 免疫学
- 罕见的遗传疾病 罕见的遗传疾病
背景情况:
- 初级免疫缺陷 (PID) 是一种影响免疫系统的罕见遗传疾病.
- 细胞功能障碍,PID的一个子集,损害了中性粒细胞的功能.
- 早期诊断和多学科管理对于PID至关重要.
研究的目的:
- 为了评估被诊断患有细胞原发性免疫缺陷的儿童的成像发现.
- 为了将放射学发现与特定的疾病和感染联系起来.
主要方法:
- 对35名被证实患有细胞功能障碍的儿童进行了回顾性研究 (2011年1月 - 2017年12月).
- 通过临床过程,呈现和实验室数据证实了诊断.
- 对成像检测结果的分析,包括淋巴腺病变,结合和肺结节.
主要成果:
- 慢性粒状体疾病 (CGD) 是最常见的疾病 (23/35名患者).
- 最常见的放射性发现是中/鼻淋巴腺病变和结合.
- 在CGD中发现了淋巴腺病和真菌感染之间,以及肺结节和肺结核/真菌感染之间的显著关联.
结论:
- 中/鼻结合是患有细胞性PID的儿童的频繁放射性表现.
- 放射学发现可以与特定的感染和诸如CGD.等潜在疾病相关联.
- 提高医生对这些成像模式的认识,可以促进早期诊断和管理.
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