遗留和新出现的 perfluoroalkyl 和 polyfluoroalkyl 物质调节男性性腺体中的类固醇生成
Samantha Daugherty1, Vanisree Mulabagal2, Joel Hayworth2
1Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn AL 36849, USA.
Endocrinology
|September 28, 2023
概括
新兴和传统的PFAS影响雄性大鼠激素分泌. 低剂量接触这些化学物质,即使在混合物中,也会改变和雌激素水平,突出显示环境风险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- perfluoroalkyl 和 polyfluoroalkyl 物质 (PFAS) 在工业和消费产品中普遍存在.
- 行业正在从PFOA/PFOS等长链 (传统) PFAS转变为PFBA/PFBS等短链 (新兴) PFAS.
- 对于新兴的PFAS存在有限的毒性数据,需要对其影响进行调查.
研究的目的:
- 为了研究低剂量的青春期前和青春期PFAS暴露对雄性大鼠淋巴腺类固醇激素分泌的影响.
- 为了比较传统和新兴PFAS的影响,单独和作为混合物.
主要方法:
- 在长埃文斯生长中的雄性大鼠被暴露在各种纳米分子度的PFAS中.
- 测量了血清和丸度的丸激素和17β-雌激醇 (E2).
主要成果:
- 传统和新兴的PFAS都改变了丸的类固醇生成.
- 在青春期前暴露于PFOS,PFBA和PFBS增加了丸激素.
- PFBA增加了丸E2,而PFOS和PFBS降低了血清E2,但增加了丸E2.
- PFAS的混合物表现出添加剂效应.
结论:
- 包括新兴类型在内的PFAS可以在环境相关的度中破坏淋巴腺类固醇激素分泌.
- 这些发现强调了需要有效的PFAS清除技术.
- 限制PFAS使用的监管行动对于保护公共健康至关重要.
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