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Updated: Jul 15, 2025

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines
10:46

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines

Published on: June 2, 2018

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转录异质性克服了多发性骨髓瘤中超强增强器破坏药物组合

Seth J Welsh1, Benjamin G Barwick2, Erin W Meermeier1

  • 1Department of Medicine, Division of Hematology/Oncology, Mayo Clinic, Scottsdale, Arizona.

Blood cancer discovery
|September 28, 2023
PubMed
概括

结合免疫调节性伊米德药物 (IMiD) 和EP300抑制,通过降低MYC和IRF4.4的调节,有效地向多发性骨髓瘤 (MM). 这种方法克服了IMiD耐药性,并提高了MM的治疗结果.

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