系统性审查的质量与复星的元分析:一个方法论系统性审查
Cuncun Lu1, Lixin Ke2, Qiang Zhang1
1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Phytotherapy research : PTR
|September 28, 2023
概括
大多数关于白醇的元分析 (MA) 的方法质量极低,报告不足. 未来的MA需要改进设计和遵守报告准则,以获得可靠的健康影响发现.
科学领域:
- 卫生科学 卫生科学 卫生科学
- 医学研究方法学 医学研究方法学
- 证据综合 证据综合
背景情况:
- 许多元分析 (MAs) 已经研究了白醇对健康的影响.
- 这些MA的方法和报告质量需要进行彻底的评估.
研究的目的:
- 进行方法系统审查,评估已公布的白醇元分析的质量.
- 确定方法和报告中的特定弱点领域.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Cochrane Library) 进行系统的搜索,直到2023年9月.
- 51个选定的管理机构的评估,使用多次系统审查评估2 (AMSTAR-2) 和2009年系统审查和元分析 (PRISMA 2009) 的首选报告项目.
主要成果:
- 大多数MA (86.27%) 在方法质量方面被评为非常低.
- 报告不够普遍,特别是在结构化摘要,协议注册,搜索策略,研究选择,数据收集,偏见风险评估和证据摘要方面.
- 只有45.10%的MAs报告了其主要结果的积极结果.
结论:
- 目前对白醇的分析显示,在方法严谨性和报告标准方面存在重大缺陷.
- 坚持建立的指导方针,如柯克兰手册,AMSTAR-2和PRISMA对于未来的元分析至关重要,以确保科学有效性和可靠性.
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