在患有肺狭窄症的狗中,对右心室的透静功能,缩功能和循环中的加勒-3度的评估
Randolph L Winter1, Kara L Maneval1, Claudio Serrano Ferrel1
1College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA.
Journal of veterinary internal medicine
|September 28, 2023
概括
狗的肺狭窄 (PS) 导致右心室 (RV) 功能障碍和高高的加列-3 (Gal-3) 水平,表明心肌纤维化. 这些发现突出了对PS的狗的临床管理的潜在影响.
科学领域:
- 兽医心脏病学 兽医心脏病学
- 心血管生理学心血管生理学
- 生物标志物研究 生物标志物研究
背景情况:
- 由于心血管疾病增加了右心室 (RV) 后负荷,导致人体的RV透静/静心功能障碍和心肌纤维化.
- 有限的研究存在于RV透静功能和心肌纤维化标志物在患有肺狭窄症 (PS) 的狗.
研究的目的:
- 为了调查与PS.狗的RV透析和收缩功能障碍的回声心脏学证据.
- 评估血清度的加勒-3 (Gal-3) 作为替代生物标志物肌肉纤维化在狗与PS.
主要方法:
- 一项前性研究涉及40只客户拥有的狗 (10对照,30个PS).
- 在所有狗中测量了全身血压,血清生物化学,心声学和血清Gal-3度.
- 使用心声回声学评估了RV的透静和静脉功能变量.
主要成果:
- 患有PS的狗表现出显著较低的RV E/A和较高的RV E/e'比率,表明腹功能障碍 (P < .001).
- 在PS (P < .001) 的狗中,RVstolic功能变量显著减少 (P < .001).
- 与对照组相比,PS患者的狗血清Gal-3度显著更高 (P = .002).
结论:
- 患有PS的狗表现出显著的RV透气和收缩功能障碍.
- 患有PS的狗的血清Gal-3度升高表明VR心肌纤维化存在.
- 结果表明,PS中的RV心肌纤维化可能会影响临床管理策略.
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