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临床显著的前列腺癌的MRI可见和不可见的组织学和转录学特征与预后有关

Timo-Pekka K Lehto^1,2,3, Juho Pylväläinen⁴, Kevin Sandeman⁵

¹Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

International journal of cancer

|September 28, 2023

概括

在MRI可见的前列腺癌显示的特征比看不见的更具侵略性. 这表明,可见病变的活检可能足以在阳性MRI扫描的男性中进行风险分层.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.
医疗成像医学成像

背景情况:

磁共振成像 (MRI) 对于前列腺癌活检分类至关重要.
临床上显著的前列腺癌 (csPCas) 的很大一部分仍未通过MRI检测到.

研究的目的:

为了确定与前列腺癌的MRI可见性相关的组织学和转录学因素.
评估这些因素与转移和前列腺癌特定死亡 (PCSD) 的关联.

主要方法:

在急性前列腺切除标本中分析了组织学组成和转录组形状 (NanoString).
确定了与MRI可见性相关的差异表达基因 (DEG) 和途径.
使用外部队列来评估DEGs的分类性能和转移和PCSD的临床参数.

主要成果:

在MRI上可见的csPCas具有较低的光线面积,与较短的存活时间相关.
67个DEG被确定,其中8个与生存相关;细胞分裂,炎症和转录调节途径在MRI可见的csPCas中被上调.
基因组 (Decipher,Oncotype DX,MSK-IMPACT) 有效地对MRI可见性进行了分类 (AUC为0.86-0.94);DEGs改善了转移和PCSD分类 (AUC分别为0.69和0.68).

结论:

在MRI可见的csPCas与MRI不可见的病变相比,表现出更具侵略性的组织学和转录学特征.
针对MRI可见病变的向活检可能足以在MRI发现阳性患者中进行风险分层.

关键词:

这就是MSK-IMPACT.型DX是DX的型型.这就是Prolaris Prolaris.生物标志物生物标志物解读它是为了破译它.

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