独立于HPV的阴茎内皮细胞瘤的谱:分类提案
Sigrid Regauer1, Mikhail Ermakov, Karl Kashofer
1Diagnostic and Research Institute of Pathology, Medical University Graz, Graz, Austria.
The American journal of surgical pathology
|September 28, 2023
概括
这项研究确定了人类乳头瘤病毒独立的阴茎状细胞癌的四种不同的前体病变. 了解这些途径,如分化阴茎内皮质瘤 (d-PeIN),对于有针对性的治疗策略至关重要.
科学领域:
- 在瘤学瘤学.
- 皮肤病理学 皮肤病理学
- 分子病理学分子病理学
背景情况:
- 人类乳头瘤病毒 (HPV) 独立的阴茎侵袭性状细胞癌 (SCC) 的前体病变与部病变相比,尚不清楚.
- 鉴别这些前体病变对于开发有效的阴茎癌诊断和治疗策略至关重要.
研究的目的:
- 分析HPV独立的阴茎前体病变的组织学和免疫组织化学特征.
- 为了将这些前体病变与邻近的侵入性阴茎SCC的组织学和突变特征相关联.
- 识别阴茎SCC发展的不同途径.
主要方法:
- 对70个HPV阴性阴茎SCC周围前体病变的组织学和免疫组织化学分析.
- 前体病变特征与相邻的SCC组织学和突变状态的相关性 (TP53,CDKN2A,HRAS,PIK3CA).
- 在前体病变和相邻瘤中评估p53和p16INK4a的表达.
主要成果:
- 确定了与60%的SCC相邻的分化阴茎内皮质瘤 (d-PeIN),与慢性炎症,p53过度表达和TP53/CDKN2A突变相关.
- 在30%的病例中发现了p53野生类型的/型前体,与具有HRAS/PIK3CA突变的/乳头SCC有关.
- 在10%的SCC中描述了未差异化的p16INK4a-负前体.
结论:
- 四种不同的HPV独立的阴茎前体病变可以分为两个主要的遗传/生物途径.
- d-PeIN途径涉及慢性炎症,p53变异和TP53/CDKN2A突变,需要特定的临床管理.
- 第二个途径涉及p53野生类型的/前体,具有HRAS/PIK3CA突变,与炎症性皮肤病不同.
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