在阿曼的Mycobacterium结核病流行病学:全基因组测序揭示了传播途径
Hamza A Babiker1,2, Amina Al-Jardani3, Saleh Al-Azri3
1Biochemistry Department, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Microbiology spectrum
|September 28, 2023
概括
全基因组测序揭示了外籍人士和阿曼国民之间以前未被认可的结核病传播. 这种基因分析有助于为阿曼的结核病控制策略提供信息.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 阿曼的结核病 (TB) 发病率超过了国家目标,来自高负担国家的外籍人士被怀疑正在传播.
- 了解结核病传播动态对于有效控制和实现终结结核病战略至关重要.
研究的目的:
- 通过全基因组测序 (WGS) 评估阿曼国家结核病传播动态.
- 调查外籍人士在阿曼结核病传播中的作用.
- 通过分析Mycobacterium tuberculosis (MTB) 隔离物的遗传相关性,为结核病控制政策提供信息.
主要方法:
- 2018-2019年68个局部MTB分离物的全基因组测序 (WGS).
- 对393个公开可用的全球结核病序列的局部隔离物进行比较分析.
- 对国民和外籍人士结核病发病率的计算.
- 使用核心基因组单核酸多态 (SNP) 距离评估遗传相关性.
主要成果:
- 结核病发病率在外籍人士中较高 (每10万人口中7.2-12.7),而在本国人中则高于 (每10万人口中3.9-3.5).
- 据WGS发现,在一名外籍人士和一名阿曼国民之间发生了传染集群,由流行病学调查证实.
- 在当地阿曼MTB菌株和来自海外原产国的全球隔离物之间观察到远距离遗传关系的证据.
结论:
- 在阿曼,WGS是补充对结核病控制的流行病学监测的宝贵工具.
- 确定外籍人士和本国人之间的传播联系是有针对性的干预措施的关键.
- 调查结果支持需要综合战略来实现终结阿曼结核病的目标.
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