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在美国儿童中对A组链球菌殖民和耳鼻炎进行长度研究
Robert W Frenck1, France Laudat2, John Liang2
1From the Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio.
The Pediatric infectious disease journal
|September 28, 2023
概括
甲型链球菌 (GAS) 喉殖民和喉炎在3-12岁的儿童中很常见. 诊断定义显著影响测量的发病率,强调病例定义对跟踪GAS感染和告知疫苗策略的重要性.
科学领域:
- 儿童传染病 儿童传染病
- 微生物学 微生物学
- 流行病学 流行病学
背景情况:
- 甲型链球菌 (GAS) 是小儿喉炎的主要原因.
- 最近严重的GAS爆发需要进一步调查.
- 了解儿童的GAS流行病学对于公共卫生至关重要.
研究的目的:
- 为了确定健康儿童中GAS喉殖民的流行率.
- 评估GAS喉炎的各种诊断病例定义.
- 为了估计GAS喉炎的发病率.
主要方法:
- 这是一项为期2年的纵向研究,对422名健康的美国儿童 (3-12岁) 进行了研究.
- 在喉疼痛发作期间,每月进行喉抽样以检测GAS培养和快速抗原检测测试验 (RADT).
- 在基线和疾病期间评估血清抗体标位 (抗斯特雷普托利辛O,抗DNaseB,抗SCP).
主要成果:
- 总体而言,GAS殖民的流行率为48%.
- 在5岁以上的儿童中观察到较高的基线抗体标位.
- 发病率根据定义有所不同:RADT/培养证明的发病率为每100人/年15.9,而血清学确认的GAS喉炎为4.6.
结论:
- 在学龄儿童中,GAS殖民和喉炎是常见的.
- 病例定义的选择显著影响了GAS喉炎的估计发病率.
- 这些发现对于GAS疫苗开发和公共卫生规划至关重要.
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