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过敏性接触性皮肤炎在患有和没有亚托皮肤炎的儿童中的患病率:多中心回顾性病例控制研究
Hadley Johnson1, Marcella R Aquino2, Alan Snyder3
1School of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota; Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Journal of the American Academy of Dermatology
|September 28, 2023
概括
患有阿托皮性皮肤炎 (AD) 的儿童经常患有过敏性接触性皮肤炎,而这种过敏性皮肤炎的诊断不足. 贴片检测对于识别AD儿童中常见的过敏原,如巴西特拉辛,至关重要.
科学领域:
- 儿科皮肤病学 儿科皮肤病学
- 过敏原识别识别过敏原识别
- 接触性皮肤炎研究
背景情况:
- 亚托匹性皮肤炎 (AD) 和过敏性接触性皮肤炎具有共同的临床和组织学特征,导致AD儿童的后者诊断不足.
- 许多患有阿尔茨海默氏症的儿童没有被转诊进行贴片检测,这阻碍了对过敏性接触性皮肤炎的准确诊断.
研究的目的:
- 更新儿童群体中常见接触过敏原的流行数据.
- 为了比较患有和没有阿托皮性皮肤炎的儿童之间的过敏原患病率.
主要方法:
- 使用儿科过敏接触性皮肤炎登记册进行回顾性病例对照研究.
- 从2018年到2022年收集的数据,包括912名儿童 (615名患有阿尔茨海默病,297名没有阿尔茨海默病).
主要成果:
- 患有阿尔茨海默症的儿童更有可能出现阳性补丁测试 (PPT) 结果,对巴西特拉辛,卡尔巴混合物和可卡米多普罗贝他因的反应更频繁.
- 阿尔茨海默病组的皮肤炎病史较长,看了更多的提供者,并表现出更普遍的皮肤炎分布.
- 在患有阿尔茨海默症的儿童中,观察到特定过敏原 (巴西特拉辛,卡巴混合物,可卡米多贝他因) 的患病率显著增加.
结论:
- 患有亚托邦性皮肤炎的儿童更容易出现阳性贴片测试反应.
- 建议对患有AD的儿童进行过敏接触性皮肤炎评估和贴片测试的转诊.
- 对过敏性接触性皮肤炎的准确诊断对于儿童患者的有效治疗至关重要.
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