身体组成,冠状动脉微血管功能障碍,以及未来心血管事件的风险,包括心力衰竭
Ana Carolina do A H Souza1, Michael H Rosenthal2, Filipe A Moura1
1Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
JACC. Cardiovascular imaging
|September 28, 2023
概括
在没有阻塞性冠状动脉疾病的患者中,低骨肌肉质量,而不是多余的脂肪,与冠状动脉微血管功能障碍 (CMD) 和不良心血管事件,特别是心力衰竭有关. 这凸显了评估危险人群肌肉质量和微血管功能的重要性.
科学领域:
- 心脏病学 心脏病学
- 身体组成分析 身体成分分析
- 血管功能 血管功能
背景情况:
- 体重指数 (BMI) 是一个有争议的心血管风险标志物,特别是在女性中.
- 冠状动脉微血管功能障碍 (CMD) 在肥胖中很常见,并且比BMI更好地预测风险,但其与身体组成的联系尚不清楚.
研究的目的:
- 通过深度学习来研究身体组成,研究CMD,骨肌肉 (SM),皮下脂肪组织 (SAT) 和内脏脂肪组织 (VAT) 之间的关系.
- 确定这些因素对被评估为冠状动脉疾病的患者不良结果的贡献.
主要方法:
- 400名血液 perfusion 和 ejection 分数正常的患者接受了心脏应激正子发射断层扫描.
- 测量了冠状动脉流量储备 (CFR);从CT扫描中量化了SM,SAT和VAT区域.
- 主要不良事件的追踪时间平均为6.0年.
主要成果:
- 肥胖患者的SAT,VAT和SM水平较高,但与非肥胖患者相比,CFR水平较低.
- 减少SM,而不是增加SAT或VAT,与CMD有关.
- 较低的CFR和SM,但不高的SAT或VAT,独立预测不良事件,特别是心力衰竭住院治疗.
结论:
- 在没有阻塞性冠状动脉疾病的女性队列中,肌肉质量减少,而不是多余的脂肪,与CMD和不良心血管结果有关.
- 评估瘦体质量和冠状动脉微血管功能可以识别患有心血管事件风险的肥胖患者.
关键词:
身体构成 身体组成心脏代谢疾病心脏代谢疾病冠状动脉微血管功能障碍心脏衰竭是因为心脏衰竭.缺血和没有阻塞性冠状动脉疾病.瘦体质量 瘦体质量 瘦体质量肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖更多相关视频
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