非常老年人和百岁老人的循环脂肪素的状态和生理意义:一项观察性研究
Takashi Sasaki1, Yoshinori Nishimoto1,2, Takumi Hirata1,3
1Center for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan.
eLife
|September 28, 2023
概括
循环中的高分子量阿迪波内克丁随着年龄的增长而增加,并且与老年人死亡率有关. 诸如遗传学和BMI等因素影响水平,在不同年龄组具有不同的意义.
科学领域:
- 老年学是一门学科.
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
背景情况:
- 高循环阿迪波涅丁与胰岛素敏感性和低糖尿病患病率相关.
- 然而,高水平与老年人 (60-70岁) 的死亡率增加有关.
研究的目的:
- 调查与循环中的高分子量 (cHMW) 氨酸相关的因素.
- 为了检查cHMW脂肪素与老年人 (85-89岁) 和百岁老人的死亡率之间的关系.
主要方法:
- 全基因组测序或基因组数据的DNA微阵列归算.
- 拉索和多变量回归用于因子分析.
- 考克斯回归用于对cHMW皮菌素量度的死亡率分析.
主要成果:
- cHMW阿迪波涅克丁水平在100岁以后增加,与糖尿病负相关.
- 在CDH13和ADIPOQ中的SNV与cHMW皮菌素有关.
- 在非常年长的男性中,较高的cHMW皮素与死亡率的增加相关;在女性中,只有在BMI调整之前才观察到这一点.
结论:
- cHMW脂肪内素水平随着年龄的增长而上升,在百岁老人中达到顶峰.
- 像BMI和HDLC这样的因素对cHMW皮质素的影响与极端年龄有很大的不同.
- 在高级年龄组中,cHMW腺素的生理意义发生了变化.
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