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富含三糖脂蛋白是否等同于低密度脂蛋白在ASCVD的风险?

Benjamin N Wadström^1,2,3, Anders B Wulff^1,2,3, Kasper M Pedersen^1,2,3

¹Department of Clinical Biochemistry, Copenhagen University Hospital - Herlev Gentofte, Borgmester Ib Juuls Vej 73, entrance 7, 4th floor, N5, DK-2730, Herlev, Denmark.

Current atherosclerosis reports

|September 28, 2023

概括

富含三糖蛋白的脂蛋白疗法可能不会单独降低动脉样硬化心血管疾病 (ASCVD) 风险. 然而,残留胆固醇与LDL胆固醇一起,有助于ASCVD,这表明治疗应该针对非高密度脂蛋白胆固醇,以更好地降低风险.

科学领域:

心脏病学心脏病学
脂质代谢脂质代谢是什么
预防医学预防医学

背景情况:

最近的临床试验没有证明,富含甘油三的降脂蛋白疗法可以降低动脉样硬化心血管疾病 (ASCVD) 的风险.
高水平的富含三糖蛋白脂蛋白及其胆固醇含量 (残留胆固醇) 被认为是ASCVD的原因,类似于低密度脂蛋白 (LDL) 胆固醇.

研究的目的:

调和有关富含甘油三蛋白脂蛋白疗法和ASCVD风险的相互矛盾的发现.
强调残留胆固醇作为ASCVD的重要贡献者的作用.
倡导一种统一的ASCVD风险评估和管理方法,以非高密度脂蛋白胆固醇为目标.

主要方法:

对观察性流行病学数据的审查.
对遗传流行病学发现的分析.
随机对照试验的评估.

主要成果:

降低残留胆固醇和LDL胆固醇可以减少ASCVD风险,比例按单位降低非高密度脂蛋白胆固醇.
目前的指导方针越来越多地建议非高密度脂蛋白胆固醇用于ASCVD风险评估,而不是单独的LDL胆固醇.
越来越多的人认为残留胆固醇和LDL胆固醇是同样重要的危险因素.

结论:

富含三糖的脂蛋白降低疗法应该旨在减少非高密度脂蛋白胆固醇,以有效降低ASCVD风险.
剩余的胆固醇在ASCVD的发病过程中起着至关重要的作用,与LDL胆固醇相似.
对ASCVD预防的综合方法需要考虑残留和LDL胆固醇水平.

关键词:

奇洛米克龙是什么意思中等密度的脂蛋白.缺血性缺血性缺血性缺血性主要的不良冠状动脉事件三甲酸甘油三甲酸甘油是什么非常低密度的脂蛋白质非常低密度的脂蛋白质.

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