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动脉样硬化在全身性红斑狼群中的发生

Rachel Tobin¹, Nidhi Patel², Kardie Tobb³

¹Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. rstobin@emory.edu.

Current atherosclerosis reports

|September 28, 2023

概括

系统性红斑狼 (SLE) 患者面临更高的心血管疾病 (CVD) 风险. 传统的工具往往忽略了这一点,需要在SLE中早期检测和治疗动脉样硬化症的策略.

科学领域:

类风湿病学类风湿病学
心脏病学心脏病学
免疫学免疫学免疫学

背景情况:

与普通人群相比,全身性红斑狼 (SLE) 患者患心血管疾病 (CVD) 的风险显著增加.
这种增加的风险在年轻的女性患者中显著,传统的心血管疾病评估工具通常不会将其评估为高风险的人群.
传统的风险模型经常低估了SLE患者的心血管风险,突出了患者评估中的关键差距.

研究的目的:

阐明SLE患者动脉样硬化发展的复杂病理生理学.
提高临床意识,了解SLE与心血管疾病发病率增加之间的复杂关系.
强调需要专门的方法来评估SLE队列中的心血管风险.

主要方法:

关于SLE和心血管疾病病理生理学的当前文献的综述.
分析导致SLE患者动脉样硬化加速的因素.
在SLE中讨论传统心血管风险评估工具的局限性.

主要成果:

在SLE中心血管疾病的风险是多因素的,涉及益风原性脂质特征,免疫失调,炎症,治疗副作用和微血管功能障碍.
传统的心血管风险模型在识别患有高动脉样硬化风险的SLE患者方面表现不佳.
非侵入性成像技术对于在SLE患者中检测亚临床心血管疾病至关重要,从而能够主动管理风险因素.

结论:

肌性硬化症患者面临着动脉样硬化性心血管疾病的增加负担,这种负担不能完全由传统的风险因素解释.
对SLE患者来说,早期识别和积极管理心血管风险因素是必不可少的.
临床医生必须警SLE和加速动脉样硬化之间的关联,以确保及时诊断和治疗,从而改善患者的治疗结果.

关键词:

动脉样硬化是一种动脉样硬化.冠状动脉微血管疾病是冠状动脉微血管疾病.炎症和心血管疾病.狼治疗方法狼治疗方法系统性红血性狼 (Systemic lupus erythematosusus) 是一种全身性狼.

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