下丘脑-垂体-甲状腺轴在非人类灵长类动物的衰老过程中发挥作用的个体特征
N D Goncharova1, A M Ermolaeva2, O A Chigarova2
1Laboratory of Experimental Endocrinology, Research Institute of Medical Primatology, Sochi, Russia. ndgoncharova@mail.ru.
Bulletin of experimental biology and medicine
|September 28, 2023
概括
与年龄有关的神经内分泌变化会影响健康. 在 rhesus 子中,类似抑郁和焦虑的行为 (DAB) 改变了甲状腺轴,激素变化与衰老期间的对照不同.
科学领域:
- 神经内分泌学神经内分泌学
- 比较医学是一种比较医学.
- 衰老研究研究 衰老研究
背景情况:
- 与年龄有关的神经内分泌变化对于个性化医学和预测病理学至关重要.
- 脑下垂体-甲状腺 (HPT) 轴的功能是理解衰老的一个关键领域.
- 抑郁和焦虑类行为 (DAB) 可能与神经内分泌失调有关.
研究的目的:
- 为了研究HPT轴功能的与年龄相关的变化.
- 为了比较实验室灵长类动物的HPT轴功能,有和没有DAB.
- 为了确定与DAB和衰老相关的特定荷尔蒙变化.
主要方法:
- 这项研究涉及年轻和老年雌性 rhesus 子.
- 行为评估将动物分类为DAB和对照组.
- 测量基底和甲状腺刺激激素 (TSH) 刺激的甲状腺释放激素 (TRH) 和自由甲状腺素 (fT4) 水平.
主要成果:
- 与对照组相比,年轻的DAB子显示出较低的基底和TRH刺激的TSH.
- 变老的DAB子表现出增加的TSH水平.
- 衰老的DAB子显示出基底和TRH刺激的FT4水平下降,与只有趋势观察到的对照组不同.
结论:
- 在 rhesus 子中,DAB 与 HPT 轴功能的明显改变有关.
- 这些变化随着年龄的增长变得更加明显.
- 研究结果强调了HPT轴在DAB和衰老中的作用,为个性化治疗策略提供了信息.
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