在SARS-CoV-2疫苗接种后,新发的无塑性贫血
Elena Chatzikalil1, Antonis Kattamis1, Panagiotis Diamantopoulos2
1Department of Pediatrics, National and Kapodistrian University of Athens Medical School, Athens, Greece.
International journal of hematology
|September 28, 2023
概括
无形性贫血是SARS-CoV-2疫苗接种的一个非常罕见的副作用. 大多数在接种疫苗后被诊断患有这种疾病的患者在标准治疗后显著恢复.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 无形性贫血 (AA) 是一种罕见的自身免疫性疾病,具有各种病因.
- 免疫病理生理学是无塑性贫血的一个常见特征.
- SARS-CoV-2 疫苗与罕见的不良事件有关,包括无性贫血.
研究的目的:
- 审查和分析报告的SARS-CoV-2疫苗接种后新出现的无塑性贫血病例.
- 讨论与疫苗相关的无塑性贫血的临床特征和管理.
- 评估无形性贫血的发病率和结果作为罕见的SARS-CoV-2疫苗相关不良事件.
主要方法:
- 在SARS-CoV-2疫苗接种后报告的无塑性贫血病例的系统审查.
- 对患者人口统计,发病时间,疾病严重程度和治疗反应的分析.
- 编制和总结临床特征和管理策略.
主要成果:
- 确定了18名患者,平均年龄为58岁.
- 无形性贫血的发病发生在接种疫苗后1天至7个月之间 (中位数为2.5周).
- 17名患者患有严重或非常严重的无形性贫血;17名患者实现了完全或部分反应,其中1人死亡.
结论:
- 无形性贫血是与SARS-CoV-2疫苗接种相关的非常罕见的潜在不良事件.
- 虽然并没有明确证明因果关系,但对于临床实践而言,意识至关重要.
- 在大多数与疫苗相关的病例中,无塑性贫血的标准治疗产生了有利的结果.
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