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Updated: Jul 15, 2026

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反应性变化对多基因测试的影响:对低度乳腺癌及其高风险21基因复发得分的基因病理分析

Anne Grabenstetter1, Edi Brogi2, Donna M Thompson2

  • 1Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. grabensa@mskcc.org.

Breast cancer research and treatment
|September 28, 2023
PubMed
概括

21基因复发分数 (RS) 测定可能会高估低度乳腺癌 (BC) 的风险,原因是反应性树皮变化. 病理学审查对于准确解释BC患者RS结果至关重要.

关键词:
活检部位发生变化乳腺癌是什么? 乳腺癌是什么化疗 化疗是一种化学疗法.脱质形成症 (Desmoplasia) 是一种复发性得分 复发性得分 复发性得分

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...