酒精使用障碍中的行走:系统性审查
Nicolaj Mistarz1, Lind Canfield1, Dorthe Grüner Nielsen1
1Department of Clinical Research, Unit for Psychiatric Research, University of Southern Denmark.
概括
患有酒精使用障碍 (AUD) 的人经常表现出步态的迹象,影响行走和下肢功能. 由于初步发现和方法上的局限性,需要进一步的研究.
科学领域:
- 神经学 神经学
- 成 药物 药物 药物 药物
- 步态分析 步态分析
背景情况:
- 慢性饮酒会损害下肢功能,并导致步态无力.
- 步行缺陷症是与酒精有关的韦尼克-科尔萨科夫综合征 (WKS) 的已知症状.
- 在没有WKS的酒精使用障碍 (AUD) 中,行走性无力症的患病率不太清楚.
研究的目的:
- 质量综合现有的关于AUD禁欲患者的步行性动症行为征兆的文献.
- 为了调查步态无力症的患病率,特别是在没有WKS的AUD患者中.
主要方法:
- 使用关键词进行系统的文献搜索,搜索"饮酒障碍"和"步态的测量".
- 搜索的数据库:EMBASE,APA PsycInfo,Medline,以及科克兰图书馆. 搜索的数据库:EMBASE,APA PsycInfo,Medline,以及科克兰图书馆.
- 包括确定研究的质量评估.
主要成果:
- 确定了10项中等到良好质量的研究 (n=37-247).
- 参与者的年龄在31.4-53.4岁之间,加权平均年龄为53.6岁.
- 在没有WKS的AUD患者中,有8项研究报告了行走性动力衰竭的行为症状.
结论:
- 有证据表明,在没有WKS的AUD患者中存在行走性动力衰竭.
- 由于异质的结果和方法的局限性,这些发现是初步的.
- 需要进一步的研究,包括对神经认知缺陷的查.
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