在老年人中解决慢性疼痛-早期认知衰退并发症:活动大脑远程有效性试验协议
Ana-Maria Vranceanu1,2, Nathaniel R Choukas1, Elizabeth A Rochon1
1Center for Health Outcomes and Interdisciplinary Research, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States.
JMIR research protocols
|September 28, 2023
概括
这项研究评估了针对慢性疼痛和认知衰退的老年人积极大脑 (AB) 计划. 早期结果显示,远程分娩的坚持性和可行性很高,这表明对身体,认知和情绪功能有潜在的益处.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 疼痛管理 疼痛管理
背景情况:
- 慢性疼痛和早期认知衰退在老年人中经常同时发生,相互恶化并加速阿尔茨海默病的发展.
- 活动大脑 (AB) 计划是第一个专门为经历慢性疼痛和早期认知衰退的老年人设计的心身干预.
- 之前的研究表明,AB程序可用于远程交付,并可以改善相关结果.
研究的目的:
- 与时间和剂量匹配的教育控制 (健康增强计划 (HEP)) 相比,确定AB计划的有效性.
- 评估AB对260名参与者的身体,认知和情绪功能自我报告和客观测量的影响.
- 根据国家卫生研究院第二阶段随机临床试验的第一年学习的经验,完善方法.
主要方法:
- 一个单盲随机临床试验,涉及260名患有慢性疼痛和早期认知衰退的参与者.
- 参与者通过多学科推,研究平台,社交媒体和社区伙伴关系来招募.
- 干预包括每周8次远程 AB 或 HEP 组会议,通过 ActiGraph 和 Fitbit 设备进行客观监测,并在基线,干预后和6个月后进行评估.
主要成果:
- 招聘于2022年7月开始,共有37名参与者在4个队伍中报名.
- 观察到高坚持率:100%完成基线评估,70%完成干预后评估,93.48%对设备监测的坚持.
- 退学率很低 (5%),在完成干预的参与者中,会议完成率为100%.
结论:
- 目前正在进行的试验旨在确认AB计划对对照干预的有效性.
- 行动机制将通过理论驱动的调解员和主持人进行调查.
- 预计这些发现将指导未来对这一群体进行多站点有效性实施试验.
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