双触发和对卵细胞质量和胚胎发育的影响:巴西队列
Isadora Ferreira Kozlowski1, Vinicius Bonato da Rosa2, Camila Dutra de Souza Francisquini3
1Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil.
JBRA assisted reproduction
|September 28, 2023
概括
与单独hCG相比,用GnRH抗剂和hCG的双重触发显著增加了接受受控卵巢刺激进行试管婴儿的妇女的检索和受精卵细胞的数量.
科学领域:
- 生殖内分泌学和不孕不育问题
- 辅助生殖技术 (ART) 是一种助孕技术.
- 卵巢刺激协议 卵巢刺激协议
背景情况:
- 触发最终卵细胞成熟是控制卵巢刺激用于体外受精 (IVF) 的关键步骤.
- 传统的触发仅使用人类胆管性腺激素 (hCG).
- 双触发,将GnRH抗剂与hCG结合起来,是一种替代策略.
研究的目的:
- 为了比较双触发与常规HCG-only触发对最终卵细胞成熟的疗效.
- 分析一组未经选择的巴西女性接受试管婴儿的结果.
- 评估对卵子检索和授精率的影响.
主要方法:
- 追溯观察性研究分析了2019年1月至2020年3月的IVF医疗记录.
- 包括335名患有不孕症的妇女.
- 两个组之间的比较:hCG触发器 (n=178) 和双触发器 (n=157).
主要成果:
- 双触发协议的结果是,与hCG-only触发相比,获得和受精的卵子总数显著增加.
- 在患者年龄,不孕症类型,体外成熟卵细胞,触发日,子宫内膜厚度,AMH度,卵泡数量,成熟卵细胞数量或受精卵细胞数量方面没有发现显著差异.
- 与卵细胞产量相关的关键指标受到双触发器的积极影响.
结论:
- 双触发协议,利用GnRH抗剂和hCG,有效地提高了在受控卵巢刺激期间检索的卵细胞总数.
- 该协议还增加了受精卵细胞的数量,这表明对试管婴儿结果的潜在益处.
- 双触发为优化特定患者群体的卵细胞产量提供了有价值的替代方案.
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