低食纤维摄入量会影响小肠的Th17和几代人内皮T细胞的发育
Charlotte J Royer1, Naomi Rodriguez-Marino1, Madelyn D Yaceczko1
1Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Cell reports
|September 28, 2023
概括
低纤维饮食会损害免疫细胞发育所必需的肠道细菌,其影响会持续几代人. 恢复肠道细菌和食纤维对于免疫健康至关重要.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 食纤维显著影响肠道微生物群的组成和功能.
- 小肠 (SI) 微生物群在宿主免疫力中起着至关重要的作用.
研究的目的:
- 研究低纤维饮食对SI微生物群和T细胞发育的影响.
- 为了确定食纤维补充或微生物群恢复是否可以逆转这些影响.
- 评估低纤维饮食对免疫功能和易受感染的长期影响.
主要方法:
- 用低纤维或高纤维饮食食小鼠.
- 使用16S rRNA测序分析SI微生物群组成.
- 在SI中评估T细胞群 (Th17,TCRαβ+CD8αβ+,TCRαβ+CD8αα+) 的情况.
- 进行微生物群移植实验.
- 评估宿主对Citrobacter rodentium感染的易感性.
主要成果:
- 低纤维饮食改变了SI微生物群,并影响了T细胞的发育.
- 食纤维补充剂部分恢复了T细胞的发育,但缺陷在几代人中持续存在.
- 低纤维食小鼠的后代显示,即使在富含纤维的饮食中,SI T细胞也减少了.
- 从食纤维的小鼠移植微生物群与富含纤维的饮食相结合是必要的,以完全恢复后代的T细胞发育.
- 低纤维饮食减少了细分丝状细菌 (SFB) 的丰富性,影响了垂直传播.
- 低纤维饮食引起的T细胞缺陷增加了对Citrobacter rodentium感染的敏感性.
结论:
- 食纤维对于维持健康的SI微生物群和适当的T细胞发育至关重要.
- 低纤维饮食可能导致持续的,跨代免疫缺陷由于改变微生物群的垂直传播.
- 恢复像SFB这样的特定细菌和确保足够的纤维摄入量对于免疫弹性至关重要.
关键词:
CD8αβ (((+) IEL 时间CP: 免疫学 免疫学CP: 微生物学 微生物学IEL T 细胞的 T 细胞.Th17 这是一个很好的方法.饮食纤维的食物纤维.介质蛋白 17 介质蛋白 17这是一种内皮层内皮质.我们的微生物群.细分的丝状细菌细分的细分细菌细分的细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分相关概念视频
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