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2型糖尿病患者吸烟和心血管疾病:一项前性观察性研究
Peder Af Geijerstam1, Fredrik Janryd2, Fredrik H Nyström1
1Department of Health, Medicine and Caring Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping.
在2型糖尿病患者中,吸烟增加了全因死亡率,但并没有增加主要心血管不良事件的风险. 这表明心脏保护药物可能会减轻吸烟.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 吸烟是一个重要的心血管疾病风险因素.
- 2型糖尿病 (T2D) 进一步增加了心血管疾病的风险.
- 抗高血压药和他类药物用于管理T2D心血管风险.
研究的目的:
- 研究吸烟对主要心血管不良事件 (MACE) 和全因死亡率的影响.
- 为了评估这些风险在一个得到良好治疗的瑞典队列的T2D患者.
主要方法:
- 这是一项前性观察性研究 (CARDIPP),对663名55-66岁的T2D患者进行了观察.
- 基线数据包括血标志物,血压和吸烟状态.
- 对MACE和所有原因死亡率的随访时间均为11.9年.
主要成果:
- 吸烟与所有原因死亡风险增加2.24倍有关 (P < 0.001).
- 在吸烟和MACE (HR 1.30,P = 0.328) 之间没有发现显著的关联.
- 在吸烟者和非吸烟者之间,基线特征和药物使用是相似的.
结论:
- 在这个T2D队列中,吸烟并没有增加MACE的风险.
- 心脏保护药物可能部分抵消吸烟对T2D的心血管损害.
- 需要进一步的研究来了解吸烟,T2D和心血管结果之间的复杂相互作用.
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