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反应性氧物种-响应性顺序向的AIE光探测器用于精确识别动脉样硬化板块

Jie Liu¹, Zhigui He¹, Yuan Zhong¹

¹Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400044, China.

ACS applied materials & interfaces

|September 28, 2023

概括

一个新的光探针 (TPAMCF) 通过向泡细胞并响应活性氧物种 (ROS) 来精确识别动脉样硬化斑块. 这允许高对比度成像,有助于心血管疾病的诊断和治疗.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
心血管研究研究心血管研究

背景情况:

动脉样硬化是心血管疾病 (CVD) 的首要原因,需要精确的斑块识别才能进行有效的临床干预.
目前的诊断方法需要改进,以准确和早期检测动脉样硬化斑块.

研究的目的:

开发一种反应性氧物种 (ROS) 响应的,顺序向的光探针,用于特定的动脉样硬化斑块识别.
为了评估探针在准泡细胞和成像斑块内的脂质滴的有效性.

主要方法:

合成了一种新型探针 (TPAMCF),将聚合诱导的排放光体与ROS可切割的链接器以及向泡细胞上的酸胺结合起来.
该探头被组装成纳米粒子,以保持水稳定性,并向向动脉样硬化斑块传递.
进行了体外和体外研究,以评估ROS响应,泡细胞结合和光成像能力.

主要成果:

TPAMCF纳米粒子通过与泡细胞的特定结合在斑块中有效积累.
探测器表现出有利的ROS响应性,在激活时释放其光体.
高对比度和精确的动脉样硬化光成像在活体样本中实现.

结论:

开发的TPAMCF探头在ROS响应和泡细胞的特定向方面表现出色.
TPAMCF纳米颗粒使得高对比度,精确的动脉样硬化斑块的体外检测.
这种光探针代表了未来在动脉样硬化斑块检测中的临床应用的有希望的候选人.

关键词:

具有ROS响应性的聚合引发的排放量聚合引发的排放量动脉样硬化的斑块脂肪液滴滴滴滴滴滴滴滴滴滴滴滴滴滴滴滴酸盐酸氨酸的含量是多少

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