慢性阻塞性肺病 (COPD) 的生活方式干预和超重:INSIGHT COPD随机临床试验
David H Au1,2, Emily Gleason1, Rachel Hunter-Merrill1
1Health Services Research and Development, Veterans Affairs Puget Sound Healthcare System, Seattle Division, Seattle, Washington.
Annals of the American Thoracic Society
|September 28, 2023
概括
对患有慢性阻塞性肺病 (COPD) 的超重或肥胖患者进行低强度的生活方式干预,导致体重减轻,但没有显著改善身体功能或呼吸障碍. 需要进一步的研究,以提高这一群体的功能结果.
科学领域:
- 肺部医学 肺部医学
- 生活方式干预措施 生活方式干预
- 临床试验 临床试验
背景情况:
- 患有慢性阻塞性肺病 (COPD) 的患者中超重和肥胖很普遍.
- 减肥干预措施对COPD功能障碍的影响尚不清楚.
研究的目的:
- 评估实用性,低强度的生活方式干预对超重或肥胖的COPD患者身体功能状态的有效性.
- 为了评估干预后6分钟步行测试距离,呼吸障碍和体重的变化.
主要方法:
- 一个为期12个月的多中心患者级实用性临床试验,涉及684名超重或肥胖的COPD参与者.
- 参与者被随机分配到通常的护理或通常的护理以及自我指导的视频生活方式干预 (糖尿病预防计划的团体生活方式平衡课程).
- 主要结局:12个月的6分钟步行测试距离;次要结局:修改的博格呼吸障碍和体重.
主要成果:
- 干预组在6分钟步行测试距离 (42.3英尺) 中呈现出统计学上显著的改善,并减少了步行后呼吸障碍 (-0.36).
- 干预组的参与者实现了适度的体重减轻 (平均差异为-1.34公斤).
- 该干预措施没有导致步行距离或呼吸障碍的临床上有意义的改善,但实现了有意义的减肥值.
结论:
- 自主指导,低强度,基于视频的生活方式干预导致超重/肥胖的COPD患者适度减肥.
- 这种干预措施并没有对身体功能状况或呼吸障碍产生临床显著的改善.
- 需要进一步的研究,以开发能够有效地改善这一患者群的功能能力的干预措施.
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