在异形性炎症性肌肉病症患者体验中的性别差异:来自COVAD数据集的子分析
Akira Yoshida1, Minchul Kim2, Masataka Kuwana1
1Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan.
Modern rheumatology
|September 28, 2023
概括
患有异常性炎症性肌肉病变 (IIM) 的女性比男性更容易感到疲劳和自身免疫多病症. 这些发现突显了IIM患者治疗结果中的关键性别差异.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 患者报告的结果
背景情况:
- 异形性炎症性肌肉病 (IIM) 是一种罕见的自身免疫性疾病,影响肌肉.
- 在IIM中基于性别的差异,特别是患者报告的结果,尚未完全理解.
研究的目的:
- 为了调查基于性别的差异,患者报告的异形性炎症性肌肉病 (IIM) 的结果.
- 分析自身免疫多病症和IIM亚型对这些差异的影响.
主要方法:
- 在自身免疫性疾病电子调查中利用国际COVID-19疫苗接种数据.
- 通过多变量分析,比较性别之间的患者报告的结果 (疲劳,疼痛,身体功能).
- 由于不同的结局概况,分别分析了包容体肌肉炎 (IBM).
主要成果:
- 分析了1197个响应;70%是女性,她们年轻,更有可能患有自身免疫多病症.
- 在非IBM IIM中,女性报告了显著更高的疲劳水平.
- 多变量分析确定了女性性别,高收入国家居住,重叠肌肉炎和自身免疫多病症作为增加疲劳的独立预测因素.
结论:
- 与男性相比,患有IIM的女性经历的疲劳更大,自身免疫多病症的患病率更高.
- 这些发现强调了IIM患者生活经验中性别差异显著.
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