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Updated: Jul 15, 2025

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
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循环无细胞线粒体DNA和抑郁症状在低活跃成年吸烟者中

Teresa E Daniels1, Emily K Zitkovsky, Laura E Laumann

  • 1From the Mood Disorders Research Program and Laboratory for Clinical and Translational Neuroscience (Daniels, Zitkovsky, Price, Tyrka), Butler Hospital; Department of Psychiatry and Human Behavior (Daniels, Kunicki, Kao, Parade, Price, Abrantes, Tyrka), and Initiative on Stress, Trauma, and Resilience (STAR), Department of Psychiatry and Human Behavior (Daniels, Parade, Tyrka), Warren Alpert Medical School of Brown University; Warren Alpert Medical School of Brown University (Zitkovsky), Providence, Rhode Island; Department of Psychological Sciences (Laumann), University of Connecticut, Storrs, Connecticut; Department of Psychiatry (Price), New York State Psychiatric Institute and Columbia University Irving Medical Center, New York, New York; Department of Molecular Biology, Cell Biology, and Biochemistry (Peterson, Dennery), Brown University; Department of Pediatrics (Dennery), Warren Alpert Medical School of Brown University, Providence; Bradley/Hasbro Children's Research Center (Parade), E.P. Bradley Hospital, East Providence, Rhode Island; and Behavioral Medicine and Addictions Research Department (Abrantes), Butler Hospital, Providence, Rhode Island.

Psychosomatic medicine
|September 28, 2023
PubMed
概括

线粒体DNA (mtDNA) 水平与吸烟和身体不活跃的成年人抑郁症症状有关. 较高的无细胞线粒体DNA (cf-mtDNA) 与抑郁和减少积极情绪相关.

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