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Updated: Jul 15, 2025

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使用高斯过程的改进的节律性分析方法可以检测干细胞中细胞密度依赖的昼夜振荡

Shabnam Sahay1,2, Shishir Adhikari3,4, Sahand Hormoz3,4,5

  • 1Department of Computer Science, Indian Institute of Technology Bombay, Mumbai, Maharashtra 400076, India.

Bioinformatics (Oxford, England)
|September 28, 2023
PubMed
概括

一种新的方法,使用高斯过程 (ODeGP) 的振荡检测,有效地检测弱和非静止的生物节奏. ODeGP的性能优于现有的方法,并揭示了基因表达的新节奏模式,例如小鼠胚胎干细胞.

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Circadian Rhythms and Gene Regulation02:19

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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