结核病类似于塞尔皮尼诺型胆管炎的患者,结核病免疫活性测试呈阴性
Sucheta Ireni1, Vidya S Mooss2, Anup Kelgaonkar3
1Uveitis and Ocular Immunology, LV Prasad Eye Institute, Hyderabad, India.
Ocular immunology and inflammation
|September 28, 2023
概括
眼结核病 (TB) 即使有负结核病检测结果,也可以表现为类似蛇形结核炎 (SLC). 及时的抗结核病治疗导致病变的消失,证明了结核病-SLC.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 类似塞尔皮因型胆管炎 (SLC) 通常与眼结核病 (TB) 相关,通过阳性结核素皮肤测试 (TST) 或干扰素释测试 (IGRA) 得到证实.
- 然而,TB-SLC的非典型表现可能发生在免疫学测试结果为负的个体中.
研究的目的:
- 调查具有阴性TST和IGRA结果但可疑患有眼结核病 (TB) 的患者的类胆管炎 (SLC) 的临床特征和治疗结果.
主要方法:
- 对在结核病流行地区被诊断患有SLC的患者进行了回顾性审查.
- 被纳入的患者有负的TST和IGRA结果,但对抗结核病治疗有积极反应.
- 治疗涉及抗结核治疗 (ATT) 和皮质类固醇的组合.
主要成果:
- 分析了15名患有活跃SLC的患者,大多数病例是双边的.
- 很大一部分患者之前曾接受过皮质类固醇或免疫抑制疗法.
- 用ATT和皮质固醇治疗导致80%的患者完全康复,在随访期间没有观察到复发.
结论:
- 眼结核病 (TB) 呈现为类似蛇形结核炎 (SLC),尽管结核素皮肤测试 (TST) 和干扰素释测试 (IGRA) 呈阴性结果,但仍可能发生.
- 这些患者的临床特征和治疗反应可能与结核病检测阳性患者相似.
- 抗结核病疗法在治疗结核病-SLC方面是有效的,即使没有积极的免疫学标志物.
更多相关视频
09:34An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
1.9K
09:54Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection
Published on: February 16, 2020
5.8K
相关概念视频
Pulmonary Tuberculosis III
357
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
357
Pulmonary Tuberculosis IV
157
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
157
Pulmonary Tuberculosis II
256
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
256
Pulmonary Tuberculosis V
194
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
194
Pulmonary Tuberculosis I
257
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
257
