CCL5/CCR5轴在阿尔茨海默病中的复杂作用
Weijiang Ma1, Aihua Liu1,2, Xinya Wu1
1Evidence-Based Medicine Team, Faculty of Basic Medical Sciences, The Institute for Tropical Medicine, Kunming Medical University, Kunming, Yunnan, China.
Journal of neuropathology and experimental neurology
|September 28, 2023
概括
在阿尔茨海默氏症 (AD) 病原发生过程中,化学激素连接体5 (CCL5) 和受体5 (CCR5) 轴的作用是复杂的和有争议的. 需要进一步的研究来澄清其在神经炎症和AD进展中的复杂参与.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 阿尔茨海默病 (AD) 呈现出显著的发病率和死亡率,患病率不断增加.
- 虽然粉样蛋白β和陶都与此有关,但它们在阿尔茨海默病发病过程中的确切作用尚不清楚.
- 神经炎症,涉及星球细胞,微质细胞和细胞因子,越来越被认为是AD发展和进展的关键因素.
研究的目的:
- 审查化学 (C-C动机) 连接体5 (CCL5) 和C-C化学受体5 (CCR5) 轴的结构,分布和生理功能.
- 总结目前对CCL5/CCR5轴在阿尔茨海默病病原发生过程中的参与的理解.
- 解决关于AD中CCL5/CCR5轴的复杂而有时矛盾的发现.
主要方法:
- 对CCL5/CCR5轴研究的文献综述.
- 对阿尔茨海默病中神经炎症的研究进行分析.
- 综合了关于化基因及其受体在神经退行症中的作用的发现.
主要成果:
- CCL5/CCR5轴参与正常的生理过程和神经退行性疾病.
- 有证据表明,CCL5/CCR5轴在AD病变发生过程中起着重要作用.
- 存在相互矛盾的研究,突出了这个轴在AD中的功能复杂性.
结论:
- CCL5/CCR5轴在阿尔茨海默氏病的发病过程中的确切作用是复杂的,需要进一步阐明.
- 了解CCL5/CCR5轴可能为AD提供新的治疗点.
- 持续的研究对于解决AD神经炎症中CCL5/CCR5的复杂性至关重要.
相关概念视频
01:26Alzheimer's Disease: Overview
513
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
513
01:22Alzheimer's Disease: Treatment
212
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
212
03:03Amyloid Fibrils
9.6K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
9.6K
01:23Role of Neurotransmitters in Memory
611
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
611