之前在急性缺血性中风患者中使用他类药物:在中国进行的一项前性队列研究
Quan Liu1, Song He2, Yapeng Lin2
1Department of Emergency, Chengdu Second People's Hospital, Chengdu, China.
Clinical neurology and neurosurgery
|September 28, 2023
概括
对于接受机械血栓切除术治疗急性缺血性中风的中国患者来说,先前使用他似乎是安全的. 然而,需要进一步的研究来证实其在改善患者结果方面的有效性.
科学领域:
- 神经学 神经学
- 心血管医学 心血管医学
背景情况:
- 机械血栓切除术 (MT) 是急性缺血性中风 (AIS) 的关键治疗方法.
- 关于先前使用他类药物对MT治疗的AIS患者结果的影响,存在相互矛盾的数据.
- 关于中国人口中这种关联的信息有限.
研究的目的:
- 调查先前使用他类药物的安全性和有效性,对中国患者进行MT.
- 为了解决缺乏关于该人口群体中他类药物的使用和MT结果的具体数据.
主要方法:
- 一项前性队列研究招募了334名用MT治疗的AIS患者.
- 患者根据先前使用他类药物的情况进行了分类.
- 结果包括90天的良好结果 (mRS 0-2),成功的再通道化 (TICI≥2b),早期的神经改善 (24小时NIHSS下降≥4),症状性脑内出血 (sICH) 和90天死亡率.
主要成果:
- 50名患者 (15.0%) 之前曾使用过他类药物.
- 在他类药物使用者和非使用者之间90天的有利结果没有显著差异 (调整后OR=0.853,P=0.626).
- 再通道化,早期神经改善,SICH和90天死亡率也显示,两组之间没有显著差异.
结论:
- 以前的他类药物使用似乎对接受MT的中国AIS患者是安全的.
- 之前使用他类药物改善这些患者的治疗结果的疗效需要进一步研究.
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