在自发脑脊液鼻的设置中多重头骨基缺陷;双机构视图
Peter Filip1, Evan A Patel1, Sarah Khalife1
1Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, IL, USA.
American journal of otolaryngology
|September 28, 2023
概括
患有多重头骨底部缺陷 (SBD) 和脑细胞的患者患脑脊液 (CSF) 泄漏的风险更高. 复发性CSF泄漏在多个SBD患者中更常见,这表明高风险人群.
科学领域:
- 神经外科 神经外科
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经学 神经学
背景情况:
- 异常性内高血压 (IIH) 涉及高脑脊液 (CSF) 压力,并可能出现CSF泄漏.
- 多重头骨基缺陷 (SBD) 和相关的CSF泄漏在IIH中的作用尚未得到广泛研究.
研究的目的:
- 调查多个SBD,脑和IIH患者中CSF泄漏风险之间的关联.
- 评估多个SBD对中枢神经液泄漏病例中术后修复失败的影响.
主要方法:
- 一个双机构的,追溯的病例控制研究.
- 将IIH患者与CSF泄漏 (病例) 与没有泄漏 (对照) 的IIH患者进行比较.
- 利用奇方位分析来评估CSF泄漏发展的统计意义.
主要成果:
- 分析了192名患者 (84例CSF泄漏病例,108例IIH对照).
- 在46.4%的CSF泄漏病例中发现了多个SBD,而对照组中则为0.9% (p < 0.001).
- 在CSF泄漏病例中 (91.6%) 与对照组相比 (3.7%) (p < 0.001) 脑细胞的形成显著增加.
- 经常发生的CSF泄漏与多个SBD (80%) 与单次泄漏 (39.1%) (p = 0.004) 相比,与多个SBD (80%) 的更高患病率有关.
结论:
- 多个SBD和脑的放射证据确定了CSF泄漏的高风险人群.
- 二次性SBD在自发的CSF鼻中普遍存在,并且在经历反复泄漏的患者中更常见.
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