开采天然产品用于先进的生物燃料和可持续的生物产品
Xiaowei Li1, Adrian E Gadar-Lopez1, Ling Chen1
1Novo Nordisk Foundation Center for Biosustainability, Danmarks Tekniske Universitet, Kongens Lyngby, Denmark.
Current opinion in biotechnology
|September 28, 2023
概括
开发可持续生物燃料的自然产品需要先进的生物信息学来挖掘生物合成基因集群 (BGC) 和宿主生物体中的功能表达. 本综述涵盖了有效开发生物基产品的工具和策略.
科学领域:
- 生物技术是生物技术.
- 代谢工程是代谢工程.
- 生物信息学是一种生物信息学.
背景情况:
- 来自可再生资源的可持续生物燃料和生物产品的需求不断增长.
- 自然产品为生物基应用提供了多样化的化学支架.
- 挑战包括精确识别生物合成基因集群 (BGCs) 及其功能表达.
研究的目的:
- 审查BGC采矿生物信息工具的进展.
- 讨论基于自然产品的生物燃料和生物产品制造的宿主操纵.
- 探索扩大化学多样性和提高产量的战略.
主要方法:
- 审查目前用于BCG发现的生物信息工具.
- 对天然产品生物合成的主体工程策略的分析.
- 讨论提高化学品多样性和生产效率的方法.
主要成果:
- 在用于识别BGCs的生物信息工具方面取得了重大进展.
- 开发各种宿主系统,用于自然产品路径的异质表达.
- 确定扩大可获得生物燃料和生物产品的范围的战略.
结论:
- 生物信息工具和主机工程对于在可持续制造中利用自然产品至关重要.
- 进一步的研究可以扩大生物制品的化学多样性和产量.
- 自然产品是利用可再生资源的有希望的途径.
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