分析非典型的 - 研究青少年月经周期的方法
Hannah Klusmann1, Tory Eisenlohr-Moul2, Kayla Baresich3
1Division of Clinical Psychological Intervention, Department of Education and Psychology, Freie Universität Berlin, Schwendenerstraße 27, 14195 Berlin, Germany.
Psychoneuroendocrinology
|September 28, 2023
概括
这项研究确定了检测有不规则周期的青少年女性排卵的准确方法. 准则提供了跟踪月经周期和荷尔蒙模式在近青春期的指导方针.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 青少年健康 青少年健康
- 神经内分泌学神经内分泌学
背景情况:
- 女人的青春期过渡涉及荷尔蒙变化,特别是在初潮期间,导致不规则和无排卵周期.
- 周末青春期与抑郁症和自杀倾向的风险增加有关,可能受到卵巢激素波动的影响.
- 在这个关键的发育阶段,研究青少年的月经周期和情感症状的方法有限.
研究的目的:
- 为了确定不规则的青少年月经周期的精确排卵检测方法.
- 制定指导方针,用于确定近青春期女性的月经周期阶段.
- 根据周期阶段和排卵状态来调查荷尔蒙和情感症状模式.
主要方法:
- 32名女性 (11-14岁) 每天提供尿样以检测雌激素 (E1G),孕 (PdG) 和黄素激素 (LH) 的代谢物.
- 对于在心理学研究中检测LH峰值或PdG上升的十种文学衍生方法的可行性进行了比较.
- 在一个月经周期中,每天对情感症状进行评分.
主要成果:
- 孙等人所使用的方法. (2019) 和帕克等人. (2007) 最准确地检测出与排卵相关的荷尔蒙变化 (LH峰值,PdG上升).
- 40.6%的周期被确定为排卵周期,在排卵周期和无排卵周期之间存在显著的荷尔蒙差异.
- 排卵周期在周排卵阶段显示较高的LH和E1G,在半排卵阶段显示较高的PdG.
结论:
- 提供了有效的指导方针,用于研究月经周期不规则的青少年的月经周期.
- 新的排卵检测方法揭示了在青少年排卵和无排卵周期中不同的荷尔蒙模式.
- 促进研究月经周期激素与女性青春期情感症状之间的联系.
相关概念视频
01:22Hormonal Regulation of the Menstrual Cycle
423
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
423
01:30Hormonal Control of the Ovarian Cycle
555
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
555
01:19The Menstrual Cycle
877
The menstrual cycle is a recurrent sequence of changes in the uterine endometrium, specifically its functional layer, the stratum functionalis. This cycle prepares the uterus for potential pregnancy. This cycle typically spans 21–35 days, averaging 28 days, and aligns with the ovarian cycle, regulated by fluctuating levels of ovarian hormones, primarily estrogen and progesterone.
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a...
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a...
877
01:27Ovarian Cycle
1.3K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.3K
01:18Menses Phase
298
The uterine cycle begins with the menstrual phase, which is considered day one of the cycle and typically lasts about five days. This phase is characterized by the degeneration and shedding of the stratum functionalis, the functional layer of the endometrium.
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
298
01:19Secretory Phase
800
The secretory phase of the menstrual cycle, spanning from day 14 to 28 in a typical 28-day cycle, is a period of significant physiological changes in the female reproductive system. This phase commences immediately after ovulation and is characterized by the preparation of the endometrium for potential embryo implantation.
Following ovulation, the corpus luteum, a temporary endocrine structure, produces progesterone and estrogens. These hormones stimulate the growth and coiling of endometrial...
Following ovulation, the corpus luteum, a temporary endocrine structure, produces progesterone and estrogens. These hormones stimulate the growth and coiling of endometrial...
800