神经性厌食症体内细胞因子的产生:一个系统的审查
K Maunder1, E Molloy2, E Jenkins3
1University College Dublin, Ireland; Children's Health Ireland - Crumlin Hospital, Ireland; Lucena Clinic, St. John of God Community Services, Ireland.
Psychoneuroendocrinology
|September 28, 2023
概括
这一系统性审查表明,IN-6 (IL-6) 可能参与厌食症 (AN) 的发病. 虽然IL-6水平在AN患者中经常升高,但在重量恢复后正常化,表明作为治疗点的潜力.
科学领域:
- 心理神经免疫学 心理神经免疫学
- 分子精神病学分子精神病学
- 饮食障碍 研究 研究 研究
背景情况:
- 神经性厌食症 (AN) 发病和进展的心理生物学尚未完全理解.
- 新兴研究表明,炎症,特别是细胞因子改变和精神疾病之间存在联系,可能在AN病变发生中发挥作用.
- 现有关于AN患者与健康对照者的细胞因子概况的研究表明异质的结果.
结论:
- 介素-6 (IL-6) 和潜在的TNF-alpha通路都与厌食症 (AN) 的发病有关.
- 跨研究的临床和方法因素的异质性限制了概括性.
- 解决未来研究中的方法缺陷至关重要,因为AN中的细胞因子改变可能为重量恢复和精神病理学提供治疗和诊断潜力.
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