瑞士专家意见:便微生物群移植的当前方法在日常实践中
Laura Rossier1, Christoph Matter1, Emanuel Burri2
1Intesto - Gastroenterology practice and Crohn-colitis Center, Bern, Switzerland.
Swiss medical weekly
|September 28, 2023
概括
便微生物种移植 (FMT) 是对C. difficile感染和性结肠炎的一种有前途的治疗方法. 这项研究制定了一个框架,在瑞士标准化FMT,改善患者获得这种治疗.
科学领域:
- 胃肠道学和微生物学
- 治疗创新 治疗创新
- 监管科学 监管科学
背景情况:
- 便微生物群移植 (FMT) 对复发性C. difficile感染和性结肠炎有希望.
- 缺乏国际共识的指导方针导致欧洲各地的FMT实践变化.
- 瑞士将便移植分类为非标准化,造成行政障碍并限制患者的访问.
研究的目的:
- 总结有关FMT的现有数据.
- 在瑞士建立一个标准化FMT使用的框架.
- 为改善患有C. difficile感染和性结肠炎的患者的FMT可用性.
主要方法:
- 一个专门研究炎症性肠病的瑞士胃肠病学家小组召开了会议.
- 文献审查和德尔菲过程被用来制定和达成关于FMT陈述的共识.
- 声明涵盖了适应症,供体查,制备,管理和安全.
主要成果:
- 建立了关于FMT实践的共识声明.
- 该框架旨在标准化FMT程序.
- 附加表详细说明了商定的陈述.
结论:
- 标准化的FMT协议对于安全和可访问的治疗至关重要.
- 该框架支持在瑞士使用FMT治疗C. difficile感染和性结肠炎.
- 预计在未来将FMT应用于其他适应症.
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