在非流利变体中语音和语法症状的神经基础初级渐进性失语谱
Diego L Lorca-Puls1,2, Andrea Gajardo-Vidal1,3,4, Maria Luisa Mandelli1
1Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, SanFrancisco, CA 94158, USA.
Brain : a journal of neurology
|September 28, 2023
概括
非流利/语法原发性渐进性失言症 (nfvPPA) 呈现出多种不同的语音和语言症状. 这项研究将nfvPPA的症状映射到大脑缩,揭示了言语失调,失联症和语法障碍的独特神经相关性,支持nfvPPA的谱视图.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 语音和语言科学 语言科学
背景情况:
- 非流利/语法原发性渐进性失言症 (nfvPPA) 的特征是异质的言语和语言缺陷,包括言语失言症 (AoS),表达性和接受性失言症,以及失言症.
- nfvPPA的表型变异性导致了关于不同的临床实体与一系列相关疾病的辩论.
- 了解这些多种症状的神经基础对于诊断和潜在的治疗干预至关重要.
研究的目的:
- 为了研究脑缩模式和特定的语音语言症状之间的关系,在NFvPPA的患者队列.
- 为了绘制语音失调 (AoS),失声症,表达性非书写主义和感受性非书写主义的神经相关物.
- 通过检查大脑-行为关系,为解决 nfvPPA 现象异质性辩论做出贡献.
主要方法:
- 一项前性队列研究,对104名具有 nfvPPA 的良好特征的患者进行了研究.
- 基于MRI的大脑缩的横截面检查.
- 区域性大脑缩和AoS的存在/严重程度,脱节症,表达性非书面主义和受体非书面主义之间的相关性分析.
主要成果:
- 对于AoS和表达性异文主义的神经相关物位于相邻的左后下额叶.
- 发病症与AoS有着明显的神经解剖相关性,涉及右半球运动语言区域和背部左半球区域,而AoS与腹部左半球区域有关.
- 表达式的表达式与左额缩有关,而接受式的表达式与语法网络中的左缩有关.
结论:
- 这些发现划分了与不同的nfvPPA表型相关的特定大脑区域,支持了一种频谱模型,而不是严格单独的实体.
- nfvPPA应该被视为一个包含一系列语音和语言症状的总称,这些症状与常见的神经解剖学和神经病理学基质联系在一起.
- 这种大脑行为映射有助于理解语音语言处理的神经基础及其在神经退行性疾病中的脆弱性.
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